Ashwagandha is a herb used in Indian medicine (Ayurvedic medicine) for nearly 3000 years. It is found in India, Middle East, and Africa. It is reported to have anti-inflammatory, anti-microbial, anti-diabetic, anti-hypertensive, neuroprotective, adaptogenic, and reproductive and hormone-modulating effects. Let's review the anti-inflammatory aspects of this herb. We will discuss NF-kB pathway modulation.
Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
https://www.mdpi.com/1999-4923/15/4/1057
Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
https://www.mdpi.com/1999-4923/15/4/1057#B41-pharmaceutics-15-01057
Ashwagandha - Special Subjects - Merck Manuals Consumer Version
https://www.merckmanuals.com/home/special-subjects/dietary-supplements-and-vitamins/ashwagandha
ASHWAGANDHA: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews
https://www.webmd.com/vitamins/ai/ingredientmono-953/ashwagandha
Ashwagandha root extract exerts anti‑inflammatory effects in HaCaT cells by inhibiting the MAPK/NF‑κB pathways and by regulating cytokines
https://www.spandidos-publications.com/ijmm/42/1/425
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-020-00312-6
Frontiers | NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration
https://www.frontiersin.org/articles/10.3389/fimmu.2019.00705/full
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https://www.frontiersin.org/files/Articles/443978/fimmu-10-00705-HTML/image_m/fimmu-10-00705-g002.jpg
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https://www.frontiersin.org/files/Articles/443978/fimmu-10-00705-HTML/image_m/fimmu-10-00705-g001.jpg
Frontiers | What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?
https://www.frontiersin.org/articles/10.3389/fcell.2019.00154/full#:~:text=Nuclear%20factor%20kappa%20B%20(NF%2D%CE%BAB)%20is%20an%20ancient,cellular%20resistance%20to%20invading%20pathogens.
IκBα - Wikipedia
https://en.wikipedia.org/wiki/I%CE%BAB%CE%B1
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2 Comments
iverjuster@*.com
Oct 04 2023, 2:31 pm
Thank you - a very enjoyable way to learn (especially compared to the way it's taught in med school). Question: If ashwagandha turns down the pathways that are designed to respond to pathogens, is it possible they make us LESS effective at fighting infections such as Covid? (Should we *in theory* advise patients with acute infection to stop taking ashwagandha until the acute phase is over ?)
canasena@*.com
Sep 09 2023, 12:18 pm
I am not sure how to edit my previous comment - I would like to add that I am also interested in Turmeric which is reported to be very effective for arthritic conditions.